Marcus Altfeld Selected Research

Infections

2/2024	Magnitude of Type I Interferon Responses by Plasmacytoid Dendritic Cells After TLR7 Stimulation Is Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir Sizes in Cisgender Women With HIV-1 on Antiretroviral Therapy.
10/2023	Early Initiation of Antiretroviral Therapy Preserves the Metabolic Function of CD4+ T Cells in Subtype C Human Immunodeficiency Virus 1 Infection.
1/2022	A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells.
1/2022	Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
9/2021	KIR3DS1 directs NK cell-mediated protection against human adenovirus infections.
1/2021	Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection.
1/2021	Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells.
12/2020	HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound.
10/2020	HIV-1 induced changes in HLA-C*03 : 04-presented peptide repertoires lead to reduced engagement of inhibitory natural killer cell receptors.
1/2020	Regulation of NK-Cell Function by HLA Class II.

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Marcus Altfeld Research Topics

Disease

104	Infections 02/2024 - 02/2002
22	Disease Progression 01/2021 - 11/2004
20	Viremia 01/2019 - 04/2003
17	HIV Infections (HIV Infection) 01/2023 - 04/2003
17	Virus Diseases (Viral Diseases) 01/2022 - 12/2003
9	Persistent Infection 11/2014 - 03/2002
6	Inflammation (Inflammations) 10/2023 - 12/2004
6	Acquired Immunodeficiency Syndrome (AIDS) 12/2016 - 08/2007
5	Neoplasms (Cancer) 01/2023 - 03/2011
5	COVID-19 01/2023 - 01/2020
4	Human Influenza (Influenza) 12/2023 - 04/2004
4	Autoimmune Diseases (Autoimmune Disease) 11/2023 - 01/2017
2	Sclerosing Cholangitis 10/2023 - 10/2019
2	Liver Diseases (Liver Disease) 10/2023 - 01/2019
2	Tuberculosis (Tuberculoses) 02/2017 - 01/2012
2	Sexually Transmitted Diseases (Sexually Transmitted Disease) 11/2004 - 09/2002
1	Pathologic Constriction (Stenosis) 10/2023
1	Ulcerative Colitis 10/2023
1	Leukoencephalopathies 01/2023
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2021
1	Stomach Neoplasms (Stomach Cancer) 12/2020
1	Amebic Liver Abscess 10/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 10/2019
1	Hepatocellular Carcinoma (Hepatoma) 01/2019
1	Non-alcoholic Fatty Liver Disease 01/2018
1	Hepatitis 01/2018
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2018
1	Fibrosis (Cirrhosis) 01/2017
1	Vesicular Stomatitis 04/2016
1	Endotoxemia 01/2016
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 06/2015

Drug/Important Bio-Agent (IBA)

31	EpitopesIBA 12/2023 - 02/2002
22	VaccinesIBA 01/2022 - 02/2002
17	LigandsIBA 12/2023 - 09/2006
17	Antiviral Agents (Antivirals)IBA 11/2023 - 04/2007
14	AntigensIBA 12/2023 - 04/2004
13	Peptides (Polypeptides)IBA 12/2023 - 09/2002
13	CytokinesIBA 01/2023 - 05/2004
9	Natural Killer Cell ReceptorsIBA 10/2023 - 09/2006
9	Proteins (Proteins, Gene)FDA Link 01/2017 - 02/2002
8	HLA-B Antigens (HLA-B)IBA 01/2019 - 12/2004
8	HLA-B57 antigenIBA 01/2015 - 12/2003
8	Interferon-gamma (Interferon, gamma)IBA 11/2014 - 04/2004
7	AntibodiesIBA 01/2023 - 09/2004
6	HLA-C Antigens (HLA-C)IBA 01/2022 - 08/2011
5	Interferon Type IIBA 11/2023 - 04/2014
5	InterferonsIBA 10/2019 - 09/2006
5	RNA (Ribonucleic Acid)IBA 01/2019 - 04/2003
5	HLA Antigens (Human Leukocyte Antigens)IBA 01/2017 - 02/2007
4	ChemokinesIBA 06/2015 - 12/2004
4	EnzymesIBA 11/2014 - 05/2004
4	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 09/2011 - 09/2002
4	Immunoglobulins (Immunoglobulin)IBA 08/2011 - 10/2008
3	KIR ReceptorsIBA 01/2019 - 11/2007
3	Tenofovir (Viread)FDA Link 10/2012 - 06/2012
3	HLA-Bw4 antigenIBA 06/2011 - 09/2006
3	Amino Acids FDA Link 12/2010 - 04/2004
2	HLA-DP Antigens (HLA-DP)IBA 10/2023 - 01/2020
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2023 - 01/2011
2	KIR2DL1 ReceptorsIBA 01/2022 - 10/2014
2	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2019 - 03/2016
2	Glycoproteins (Glycoprotein)IBA 04/2016 - 01/2015
2	Broadly Neutralizing AntibodiesIBA 11/2014 - 01/2011
2	Neutralizing AntibodiesIBA 11/2014 - 04/2003
2	Protein Subunits (Protein Subunit)IBA 08/2014 - 01/2012
2	Staphylococcal Protein A (Protein A)IBA 04/2014 - 10/2010
2	Interleukin-2 (IL2)IBA 01/2013 - 01/2011
2	Toll-Like Receptors (Toll-Like Receptor)IBA 03/2012 - 06/2007
2	Interleukin-10 (Interleukin 10)IBA 01/2011 - 06/2010
2	Peptide Hydrolases (Proteases)FDA Link 11/2010 - 05/2004
2	Isoleucine (L-Isoleucine)FDA Link 08/2007 - 09/2006
2	AIDS VaccinesIBA 11/2006 - 03/2006
2	HLA-A3 Antigen (HLA A3 Antigen)IBA 07/2004 - 09/2002
1	NK Cell Lectin-Like Receptor Subfamily CIBA 12/2023
1	HLA-DPA1 antigen (HLA DPA1)IBA 10/2023
1	Glucose (Dextrose)FDA LinkGeneric 01/2023
1	Interleukin-6 (Interleukin 6)IBA 01/2023
1	Retinaldehyde (Retinal)IBA 01/2023
1	Signaling Lymphocytic Activation Molecule FamilyIBA 01/2021
1	AndrogensIBA 10/2020
1	Testosterone (Sustanon)FDA Link 10/2020
1	Granzymes (Granzyme)IBA 10/2019
1	LipopolysaccharidesIBA 01/2019
1	CEACAM1 ProteinIBA 01/2018
1	DefensinsIBA 01/2017
1	SteroidsIBA 01/2017
1	Hormones (Hormone)IBA 01/2017
1	Heme (Haem)IBA 01/2017
1	Cell Surface ReceptorsIBA 01/2017
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2017
1	Heme Oxygenase-1IBA 01/2017
1	Messenger RNA (mRNA)IBA 01/2016
1	Pathogen-Associated Molecular Pattern MoleculesIBA 06/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2014

Therapy/Procedure

13	Therapeutics 10/2023 - 04/2003
7	Highly Active Antiretroviral Therapy (HAART) 01/2023 - 11/2004
4	Art Therapy 02/2024 - 09/2011
3	Liver Transplantation 10/2023 - 01/2017